Artificial Intelligence strengthens proteome research

The TUM team

The TUM team

Proteomes are the entire set of proteins in an organism possible to be expressed at a specific time. These proteins are important factors in an individual's genome and DNA blueprinting, and control the majority of daily functions. Their presence is vital in the avoidance of defective diseases or illnesses. Thus, researchers analyze proteins to find which can be used for specific therapies and to discover the differences and similarities many of them hold among each other. Yet, the analysis of these proteins is quite a difficult process - serving as a severe obstacle for medical researchers and scientists who attempt to engender cures for diseases. Fortunately, artificial intelligence has become the catalyst in this process, facilitating the researcher's process in overcoming this challenge efficiently. In fact, the way artificial intelligence performs in this process is almost error-free and perfect, which will likely result in the widespread usage of this prototype in a variety of medical and laboratory fields. 

Prosit, the name of the artificial intelligence prototype, was engineered at the Technical University of Munich in Germany. The team responsible for this discovery was bioinformatics scientist Mathias Wilhelm and biochemist Bernhard Küster, Professor of Proteomics and Bioanalytics. Their motivation for designing this prototype lied in the failures of mass spectrometry - the previous method used to analyze proteins. Mass Spectrometry, while temporarily suitable, has many key failures - including the fact that it does not measure proteins directly. It measures smaller parts of amino acid sequences rather than locating the big picture - making the probability of error larger than necessary. Thus, many proteins are identified incorrectly or not recognized. 

A Mass spectrometry machine

A Mass spectrometry machine

In comparison to Prosit, these errors mass spectrometry holds are nonexistent. The neural network developed by the TUM team utilizes all the information of the spectra for the process of identification. "We miss fewer proteins and make 100 times fewer mistakes," says Bernhard Küster. Furthermore, Prosit is much more applicable to a diverse assortment of scenarios. Previously uncomprehensible research can be broken down with the strength of Prosit. Its abilities lie in its large assortment ability to store and recognize all existing proteins among organisms without resulting in stress or tension on the computer. Mathias Wilhelm believes that every species on the planet can be recognized under Prosit, and each protein will be analyzed thoroughly in order to bolster scientific research. 

Already, biotech companies and clinics are attempting to get their hands on Prosit. It is inevitable that Prosit will launch a reputable position among the medical and technological sector, as a result of its incredulous accomplishments. Thus, it's probable that the market will grow to near billions for the TUM team. Furthermore, it is also valid that future research will be conducted as a result of Prosit's success. Prosit will aid in the developing of more medical cures, advancements, and discoveries. Researchers will become stronger in monitoring patients and organizing thorough therapies for their wellbeing. 

Thus, researchers have monumental hope for Prosit and its abilities in proteome research. The method can be used to track down new regulatory mechanisms in cells," says Küster. "We hope to gain a considerable amount of knowledge here, which, in the medium and long term, will be reflected in the treatment of diseases suffered by humans, animals, and plants." Wilhelm also expects that "AI methods such as Prosit will soon change the field of proteomics, as they can be used in almost every area of protein research." To dominate the medical industry will not be a surprise for Prosit. It will be inexorable for Prosit to extend its abilities across protein research to the entire field of the medical industry in the process of establishing the health of not only humanity but all organisms equally. 

HealthcareYousef Khan